The topics of the monographic course are necessary to what is present in the main Biochemistry course and to understand also the topics that will be subsequently proposed in other courses eg Clinical Biochemistry, Hematology etc. The topics of the program are necessary to the practical knowledge of the profession and to understand the topics that will be discussed later on in other disciplines. Through the acquisition of the knowledge provided by the Monographic Course, and through the ability to understand their application in the professional field, the student is able to acquire additional skills useful for the understanding of simple clinical cases that may arise during the specialistic field. Blood, general concepts; blood composition; blood count; erythrocytes, erythrocyte metabolism; leukocytes, leukocyte metabolism; platelets; platelet metabolism; coagulation; hemoglobin and myoglobin; hemoglobinopathies; blood groups; hematopoiesis; plasma and plasma proteins; plasma markers; lipidomics. The assessment of learning is done through a written test, multiple-choice test, after checking the presence during the frontal lessons.

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Saranno approfonditi, in particolare, i meccanismi molecolari alla base della fisiologia umana, della patologia e della farmacologia, con particolare riguardo alla Medicina di Precisione. Voet, Charlotte W. Pratt - - Zanichelli Biochimica con aspetti clinici - Thomas M. Devlin - - EdiSes Biochimica generale.

Con elementi di biologia molecolare - F. Salvatore et al. Moran, K. Scrimgeour, H. Hochs, J. Berg, J. Tymoczko, L. Modelli di interferenza farmacologica con le vie biochimiche studiate saranno inoltre discussi. Per frequentare con competenza il Corso di Biochimica, gli studenti devono aver acquisito una solida esperienza in Chimica e Propedeutica Biochimica, Biologia e Biologia Molecolare, e Fisica. I docenti saranno a disposizione durante tutta la durata del corso, e successivamente, per fornire spiegazioni sugli argomenti trattati durante le lezioni e supportare gli studenti durante il loro percorso formativo.

Le molteplici funzioni biologiche delle proteine. Livelli di organizzazione strutturale delle proteine. Struttura primaria. Struttura secondaria. Struttura terziaria. Struttura quaternaria. Proteine fibrose e proteine globulari. Anemie: definizione e classificazione. Le principali emglobinopatie. Tappe di sintesi e maturazionne del collageno.

Le principali collagenopatie. Adattamento indotto. Isoenzimi; loro significato in Biochimica sistematica; implicazioni biochimico-cliniche. Regolazione covalente, reversibile fosforilazione, metilazione, acetilazione, adenilazione e irreversibile zimogeni e proteolisi limitata ; vie metaboliche o catene di enzimi: regolazione a feedback.

Concetto di tappa limitante ed enzima regolatore. Proteine ed enzimi inducibili e costitutivamente espressi. Funzioni biologiche, organizzazione strutturale, nomenclatura e classificazione. Ormoni e recettori. Le vie metaboliche. Principi di bioenergetica. Le leggi della termodinamica. La variazione di energia libera. Il trasferimento dei gruppi fosforici e l'ATP. L'energia libera di idrolisi dell'ATP. Glicogeno, metabolismo e funzioni; glicogenosintesi, glicogenolisi, reazioni, enzimi, regolazione.

Deficit di G6PD e favismo. Lattato deidrogenasi e suoi isoenzimi. I pigmenti biliari. Ruolo del folato e suoi derivati. Il ciclo dei folati e suoi inibitori. Le reazioni di transmetilazione. S-adenosilmetionina e S-adenosilomocisteina. La morte cellulare programmata. Via intrinseca mitocondriale ed estrinseca death receptors. Ruolo della proteina P Le caspasi e loro attivatori e substrati. Apoptosi e malattie cenni. The Biochemistry Course, which is organized in two semesters, provides an overview and in-deep discussion of the main aspects of medical-oriented Biochemistry, starting from studying the biomolecules and macromolecules of biological interest, their hierarchical structure and their assembly into complexes responsible for specific biological processes.

Particulary attention will be paid to the molecular and biochemical mechanisms at the base of the human Physiology, Pathology and Pharmacology, and of the newly-born concept of Precision Medicine.

The Biochemistry Course is aimed to provide medical students with the fundamental chemical and biological bases for the comprehension of the physiological mechanisms of the biochemical homeostasis, both at cellular and systemic level, and for gaining the ability to interpret the biochemical changes occurring in human diseases. Students will acquire knowledge on i.

Models of pharmacological interference with the studied biochemical pathways will be discussed. At the end of the course the students will have acquired the principles driving the modern precision molecular medicine and the cultural back-ground necessary for approaching the studies of Physiology, Pathology, Immunology, Pharmacology and Medical Clinics at molecular level.

To attend proficiently the Biochemistry Course, students need to have acquired a well-established background in Chemistry and Propaedeutic Biochemistry, Biology and Molecular Biology, and Physics. Access to the exam is regulated by passing the preliminary exams, as established by the Degree Course Council.

Frontal lessons will be delivered by means of Power Point files projection or other tools. Throughout lesson, discussion will be stimulated to give elucidations and further insights on the topics object of the study.

Teachers will be available throughout the course and afterwards, to provide explanations on each biochemical aspect studied and to support students during their training. The final exam includes a written test followed by an oral examination. A mid term exams quiz including 30 multiple choice questions might be administered at the end of the first semester. This will not sum up with the final score and it is uniquely aimed at encouraging the students to challenge with apprenticeship of the first group of topics.

The final exam includes a written test including 30 multiple choice questions - 1 point of score will be given, to any right answer, no penalty for wrong answers on all topics.

An oral test will follow, aimed at ascertaining the learning of the topics addressed during the Biochemistry course. The student must demonstrate a deep knowledge of the structural aspects of the main classes of biomolecules and of the regulation of the main metabolic pathways with particular attention to the mechanisms of the most common pathologies.

The final grade is expressed in 30th, where 18 represents the minimum and 30 the maximum. The material used for the lectures will be shared electronically pdf file. Importance of structural stability and tridimensional organization of the biological macromolecules. The peptidic bond and its geometry and features. Protein posttranslational modifications.

Structure-function relationships. Multiple biological functions of proteins. Peptides with biological functions. Protein families. Protein primary structure Electronic and geometric features of the peptide bond and secondary structure. Tertiary structure. Quaternary structure.

Fibrous proteins and globular proteins. Fibrillar proteins: structural and functional properties. Keratin, collagen, elastin. Proteoglycans and the extracellular matrix ECM. Biosynthesis and post-biosynthetic processing.

Globular proteins. Strutural level. The heme group. Hb saturation dissociation curve. Bohr effect. Mechanisms for maintenance of reduced state of iron within heme: methemoglobin reductase. Transport of CO2: role of Hb, role of carbonic anhydrase, role of bicarbonates. Anemia: definition and fundamental aspects. Some examples anemias: thalassemias, sickle cell anemia, favism see also reference to pentose phosphate pathway. Collagen: amino acid composition and triple helix structure of the tropocollagen.

Synthesis and maturation stages of collagen. The main collagen diseases. Thermodynamics of chemical reaction. Free energy variation of enzyme-catalyzed reaction.


Biochimica con aspetti clinici

Saranno approfonditi, in particolare, i meccanismi molecolari alla base della fisiologia umana, della patologia e della farmacologia, con particolare riguardo alla Medicina di Precisione. Voet, Charlotte W. Pratt - - Zanichelli Biochimica con aspetti clinici - Thomas M. Devlin - - EdiSes Biochimica generale. Con elementi di biologia molecolare - F. Salvatore et al. Moran, K.


Devlin, Thomas M.

Free file hosting download links for devlin biochimica con correlazioni cliniche in ebookee. You can search and download any epub, mobi and pdf ebooks at ebookee.. Devlin, Biochimica con aspetti clinici, Edises Ed. Title: Microsoft.


ISBN 13: 9788879472876

Biochimica con aspetti clinici by Thomas M. Search results. Biochimica con aspetti clinici. Show results for New Arrivals Next 90 days. Shopbop Designer Fashion Brands. Biochimica con aspetti clinico-farmaceutici by Thomas M Devlin Book 2 editions published in in Italian and held by 5 WorldCat member libraries worldwide.


84898 - General and Molecular Biochemistry

The course aims to provide a preparation in Biology and Genetics adequate to the understanding of the basics of modern Molecular Cell Biology, Classical and Molecular Genetics. At the end of the course the student will acquire the basics of the morphology and function of specific cellular apparati, as well as how the genetic information flows. Learning of these notions will make clear to the student the transition mechanisms from genotype to phenotype, both in physiological and pathological conditions. The course of Biochemistry aims to provide to the students the basis to understanding the physical, chemical and biological contexts in which molecules, reactions and metabolic pathways play their role. At the end of the present course the student will understand the structure-function relationships of the main biological molecules, essential biochemical mechanisms that underlie a proper metabolic function and the consequences of their alterations. Email: dbarbaga unict. Email: ravola unict.

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