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Received: July 1; Accepted: December Hemangiopericytoma is a rare vascular tumor of the sinonasal region, associated with epistaxis and nasal obstruction as the main symptoms. When located in this region, it has special clinical characteristics that differentiate it from others. The following paper reports the case of a year-old female patient presenting with right nasal obstruction and 6 months of evolution associated with mucopurulent rhinorrhea and recurrent right side epistaxis.
Physical examination showed a right obstructive mass originating from the cribriform plate. Computed tomography of the paranasal sinuses revealed a complete blockage of the right nasal cavity by a homogeneous content, with soft tissue density and no evident contrast enhancement. The lesion extended superiorly to the cribriform plate but without intracranial or orbital extension. The patient was treated with endoscopic surgery and anatomopathological study revealed sinonasal hemangiopericytoma.
The patient had complete remission and subsequent 3-year follow-up without recurrence. The recommended treatment for hemangiopericytoma is total surgical excision with free margins. The results are generally good and the risk of recurrence seems to be associated with incomplete tumor excision. A literature review is presented and its main characteristics are discussed.
Hemangiopericytomas are tumours of vascular origin that are rarely seen in the nose and paranasal sinuses. Its designation as 'hemangiopericytoma-like' tumor implies that it is related to, yet distinct from, soft tissue hemangiopericytomas. From a therapeutic point of view, the mainstay of treatment is surgical excision with clear resection margins, as these tumors are relatively radioresistant.
Nowadays, given the extraordinary development of endoscopic techniques, sinonasal hemangiopericytoma can be managed endonasally, with very few exceptions. A year old Caucasian female patient, teacher, with no relevant medical history, presented to our hospital with complaints of right nasal obstruction of 6 months of evolution, associated with mucopurulent rhinorrhea and recurrent right side epistaxis.
Physical examination showed a right obstructive mass originating from the roof of the nasal fossa cribriform plate , which caused a deviation of the nasal septum to the left and a lateralization of the middle turbinate to the right Figure 1 A. Figure 1. A Rhinoscopy: Obstructive mass originating from the roof of the right nasal fossa. Computed tomography of the paranasal sinuses CT-PS revealed a complete blockage of the right nasal cavity by a homogeneous content, with soft tissue density, without evident contrast enhancement.
This neoformation caused bulging with thinning and remodeling of the septum and the wall of the right maxillary sinus. The lesion extended superiorly to the cribriform plate but without intracranial or orbital extension, and posteriorly through the choana to the nasopharynx Figure 1 B.
CT scan of the neck and thorax did not identify relevant alterations. A biopsy of the lesion was performed and the histological study revealed an inflammatory polyp with no signs of malignancy. The patient underwent endoscopic surgery with en bloc resection of the lesion that originated in the cribriform plate of the ethmoid Figure 1 C , without sequelae associated with the procedure.
The anatomopathological study of the surgical specimen revealed a tumor with morphological and histochemical characteristics compatible with sinonasal hemangiopericytoma and immunoreactivity to vimentin, CD34 and alpha-actin Figure 2. Figure 2. Anatomopathological study: Polyp lined by respiratory epithelium, expanded chorion by proliferation of cells of elongated nuclei, sometimes fusiform in appearance.
Immunoreactivity for vimentin, CD34 and alpha-actin. Characteristics suggestive of sinonasal hemangiopericytoma. HE -Hematoxylin-Eosin.
The patient underwent a 3-year follow-up, during which time she remained free of symptoms and showed no signs of local or meta-static recurrence on objective examination and CT-PS imaging Figure 3. Figure 3. A After removing hemangiopericytoma; B Endoscopic examination without evidence of local recurrence 3-year follow-up.
Hemangiopericytoma, also known as extrapleural solitary fibrous tumor, is a rare tumor, initially described by Stout and Murray in Its origin is usually benign but its biological behavior and natural history are still relatively unknown, with a potential risk of malignancy. Sinonasal hemangiopericytoma presents some histological and biological differences with respect to hemangiopericytomas in other places, and is often known as 'hemangiopericytoma-like' sinonasal tumor.
Some authors suggest a similarity with glo-mus tumors. However, unlike lobular capillary hemangiomas and solitary fibrous tumors, it rarely stains positively for CD34, although staining for CD34 and S protein can be focally and weakly positive in a small percentage of tumors. These lesions occur mainly between the ages of 40 and 60, affecting both females and males. The most common initial presentation is nasal obstruction and recurrent epistaxis.
The lesions are usually painless and the symptoms are originated by their growth and tumor compression. The initial diagnostic assessment must include endoscopic and neuro-radiological evaluation with CT and magnetic resonance imaging MRI.
CT imaging demonstrates tumor involvement of the soft tissue in the nasal cavity and paranasal sinsuses, with bone destruction observed in large tumors.
MRI shows sinonasal hemangiopericytoma as a solid mass with isotense signals on contrast-enhanced T1 imaging, which is useful for differentiating it from inflammatory fluid caused by sinus obstruction. Imaging evaluation allows the characterization of tumor extension and its relation with adjacent structures, namely, intracranial and intraorbital components.
Biopsy of sinonasal lesions, which are suspected of being vascular tumors, is not routinely performed by our department in the outpatient clinic. Nevertheless, in this case, a biopsy was performed considering that physical examination and CT scan did not present strong evidence of a vascularized lesion. Based on the biopsy results, only sinonasal polyposis was suspected initially, therefore, no preoperative magnetic resonance imaging was performed. Although this is a limitation, it had no influence on the procedure and surgical outcome, since complete resection of the lesion was achieved without associated complications and without recurrence after 3 years of follow-up.
Malignant lesions have an increased risk of recurrence and are associated with cellular pleomorphism, moderate to severe nuclear atypia, bone invasion, and tumor necrosis. Some authors state that the presentation of hemangiopericytoma at the sinonasal level is less aggressive but locally recurrent.
The treatment of choice is endoscopic surgical resection with free margins, with positive margins being the main positive predictive factor for recurrence of hemangiopericytoma. High recurrence rates are probably associated with the difficulty of total excision of the tumor at this location. The use of chemotherapy is controversial and its efficacy has not been proven. With less than cases of sinonasal hemangiopericytomas reported in the literature, only limited assumptions can be made about the tumor.
Historically, open surgical methods for tumor extirpation have been considered as standard treatment, although endoscopic resection has increased in recent decades.
Hemangiopericytoma is a rare tumor in the sinonasal region with usually benign etiology. Adequate surgery with free resection margins is the treatment of choice. Nowadays, with very few exceptions, resection should be conducted endoscopically. Patient outcome is generally good, and the risk of recurrence seems to be related to complete resection.
Hemangiopericytoma: a vascular tumor featuring Zimmermann's pericytes. Ann Surg. Compagno J. Hemangiopericytoma-like tumors of the nasal cavity: a comparison with hemangiopericytoma of soft tissues. Intranasal pericytic tumors glomus tumor and sinonasal hemangiopericytoma-like tumor : report of two cases with review of the literature. Pathol Int. Surgical resection of sinonasal hemangiopericytoma involving anterior skull base: Case reports and literature review. Am J Otolaryngol. Sinonasal hemangiopericytoma: A rare case report with review of literature.
J Oral Maxillofac Pathol. Endoscopic, endonasal management of sinonasal haemangio-pericytoma: year experience. J Laryngol Otol.
Case Rep Otolaryngol. Sinonasal-type hemangiopericytoma: a clinico-pathologic and immunophenotypic analysis of cases showing perivascular myoid differentiation. Am J Surg Pathol. Endoscopic management of sinonasal hemangiopericytoma. Otolaryngol Head Neck Surg. Systematic review of treatment and prognosis of sinonasal hemangiopericytoma.
Head Neck. Al Saad S. Glomangiopericytoma Hemangiopericytoma of the maxillary sinus and sinonasal tract. Hematol Oncol Stem Cell Ther. Management of sinonasal hemangiopericytomas: a systematic review. Int Forum Allergy Rhinol. Sinonasal Hemangiopericytoma: A Case Report. Iran J Med Sci. It is currently being managed in Colombia by the Universidad Nacional de Colombia. Latin American and Caribbean literature in health sciences is the most important and comprehensive index of scientific and technical literature of Latin America and the Caribbean.
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