Folk medicinal plants are potential sources of useful therapeutic compounds including some with antiviral activities. Extracts prepared from 10 South American medicinal plants Baccharis trinervis, Baccharis teindalensis, Eupatorium articulatum, Eupatorium glutinosum, Tagetes pusilla, Neurolaena lobata, Conyza floribunda, Phytolacca bogotensis, Phytolacca rivinoides and Heisteria acuminata were screened for in vitro antiviral activity against herpes simplex type I HSV-1 , vesicular stomatitis virus VSV and poliovirus type 1. The most potent inhibition was observed with an aqueous extract of B. Good activities were also found with the ethanol extract of H. The aqueous extracts of T.
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HIV: replication mechanism, pharmacological targets and inhibition by products derived from plants. The AIDS epidemy has spread out and led to the diversification on the research for new antiviral drugs.
Natural products, especially those derived from plants, are well-recognized as excellent sources of new drugs. Several of them have inhibitory activity against HIV replication, and some have been already clinically tested, with favorable results. This review presents the biochemical basis of the viral cycle and the research up to date on the identification, determination of the mechanism of biological action together with the therapeutical potential of plants-derived natural products, in the inhibition of HIV.
Keywords: HIV; natural products; antiviral. Toda esta morbi-mortalidade estimulou o desenvolvimento de terapias antirretrovirais. Outras atividades anti-HIV de produtos naturais. A 1,4-fenantrenoquinona denbinobina 16 , foi isolada de uma variedade de Cannabis sativa. Vaishnav, Y. Campbell, R. Adamson, C. Today , 13 , Hardman, J. Aiken, C. Turriziani, O. Agents Chemother. Cos, P. Calderone, V. HIV Res. Lam, T. Manganelli, R. Fujioka, T. Cunico, W.
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Antiviral Activity of Some South American Medicinal Plants